11C-PiB-PET; 18F-FDG-PET; Alzheimer's disease; conversion prediction; dementia; early diagnosis; mild cognitive impairment; prognosis 11C-PK11195; Alzheimer's disease; TSPO-PET Imaging; astrocytosis; microglia activation; molecular imaging; neurodegenerative disorders; neuroinflammation 18F-FDG PET ; MRI ; SPM ; gamma knife ; radiotoxicity; tomotherapy 18F-FDG-PET; Dementia with Lewy bodies; Metabolic connectivity; NPI; Visual hallucinations Aging; Amyloid; Concussion; Dementia; Neurodegenerative; PET; Traumatic brain injury Alzheimer's disease; A$beta$; Dementia; MCI; PET; Tau Alzheimer's disease; Amyloid burden; Positron emission tomography/computed tomography; SUVr Alzheimer's Disease; Amyloid imaging; Brain atrophy; Dementia; Tau imaging Alzheimer's disease; Amyloid; Apolipoprotein E; Positron emission tomography; Sex differences; Tau Alzheimer's disease; Amyloid; Flortaucipir; Functional connectivity; PET; Tau Alzheimer's disease; Biomarkers; CSF; Flortaucipir; PET; Tau Alzheimer's disease; Biomarkers; Mild cognitive impairment; Neuropsychology; Positron emission tomography; Psychometrics Alzheimer's disease; connectivity; dementia; dopamine systems; mild cognitive impairment; ventro-tegmental area Alzheimer's disease; EOAD; LEADS; YOAD; early-onset; young onset Alzheimer's disease; flortaucipir; qualitative assessment; tau positron emission tomography; visual assessment Alzheimer's disease; neurofibrillary tangle; neuropathology; positron emission tomography; tau Alzheimer's disease; PET; amyloid; hypometabolism; tau Alzheimer's; FDG; PET; Tau; diaschisis amyloid; neurodegeneration; spatial extent; tau; topography Amyloid; Neuroinflammation; PET molecular imaging; Protheinopathies; Radiotracers; Tau Amyotrophic lateral sclerosis; Biomarkers; Brain metabolism; Diagnosis; [18F]FDG-PET Biomarker: diagnosis Creutzfeldt-Jakob disease; Microglia activation; PET; Postmortem examination; Prion disease EAE monophasic model; MRI; Multiple sclerosis; Neuroinflammation; TSPO-PET early onset Alzheimer's Disease; frontal lobe; functional networks; metabolic connectivity; neuropsychiatric subsyndromes; positron-emission tomography Early-onset Alzheimer's disease; Microglia activation; Positron emission tomography; [11C]-(R)-PK11195 PET; [18F]-FDG PET FDG; PET; connectivity; default mode network; resting-state network; synuclein PET; amyloid; biomarker; dementia; diagnosis; fluorodeoxyglucose; molecular imaging; neuroinflammation; prognosis; tau prognosis; Brain metabolism; Dementia with Lewy bodies; FDG-PET SPM analysis; Tourette's syndrome; cerebral metabolism; prefrontal cortical stimulation; tics

2022

Iaccarino, Leonardo; Joie, Renaud La; Koeppe, Robert; Siegel, Barry A; Hillner, Bruce E; Gatsonis, Constantine; Whitmer, Rachel A; Carrillo, Maria C; Apgar, Charles; Camacho, Monica R; Nosheny, Rachel; Rabinovici, Gil D; Initiative, Alzheimer's Disease Neuroimaging

rPOP: Robust PET-only processing of community acquired heterogeneous amyloid-PET data Journal Article

In: Neuroimage, vol. 246, no. 118775, pp. 118775, 2022.

Abstract | BibTeX | Tags:

2021

Apostolova, Liana G; Aisen, Paul; Eloyan, Ani; Fagan, Anne; Fargo, Keith N; Foroud, Tatiana; Gatsonis, Constantine; Grinberg, Lea T; Jack, Clifford R Jr; Kramer, Joel; Koeppe, Robert; Kukull, Walter A; Murray, Melissa E; Nudelman, Kelly; Rumbaugh, Malia; Toga, Arthur; Vemuri, Prashanthi; Trullinger, Amy; Iaccarino, Leonardo; Day, Gregory S; Graff-Radford, Neill R; Honig, Lawrence S; Jones, David T; Masdeu, Joseph; Mendez, Mario; Musiek, Erik; Onyike, Chiadi U; Rogalski, Emily; Salloway, Steve; Wolk, David A; Wingo, Thomas S; Carrillo, Maria C; Dickerson, Bradford C; Rabinovici, Gil D; Consortium, LEADS

The Longitudinal early-onset Alzheimer's disease Study (LEADS): Framework and methodology Journal Article

In: Alzheimers. Dement., vol. 17, no. 12, pp. 2043–2055, 2021.

Abstract | BibTeX | Tags: Alzheimer's disease; EOAD; LEADS; YOAD; early-onset; young onset

Asken, Breton M; Mantyh, William G; Joie, Renaud La; Strom, Amelia; Casaletto, Kaitlin B; Staffaroni, Adam M; Apple, Alexandra C; Lindbergh, Cutter A; Iaccarino, Leonardo; You, Michelle; Grant, Harli; Fonseca, Corrina; Windon, Charles; Younes, Kyan; Tanner, Jeremy; Rabinovici, Gil D; Kramer, Joel H; Gardner, Raquel C

Association of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults Journal Article

In: Brain Imaging Behav., vol. 15, no. 5, pp. 2417–2425, 2021.

Abstract | BibTeX | Tags: Aging; Amyloid; Concussion; Dementia; Neurodegenerative; PET; Traumatic brain injury

Ljubenkov, Peter A; Edwards, Lauren; Iaccarino, Leonardo; Joie, Renaud La; Rojas, Julio C; Koestler, Mary; Harris, Baruch; Boeve, Bradley F; Borroni, Barbara; Swieten, John C; Grossman, Murray; Pasquier, Florence; Frisoni, Giovanni B; Mummery, Catherine J; Vandenberghe, Rik; Ber, Isabelle Le; Hannequin, Didier; McGinnis, Scott M; Auriacombe, Sophie; Onofrj, Marco; Goodman, Ira J; Riordan, Henry J; Wisniewski, Gary; Hesterman, Jacob; Marek, Ken; Haynes, Beth Ann; Patzke, Holger; Koenig, Gerhard; Hilt, Dana; Moebius, Hans; Boxer, Adam L

Effect of the histone deacetylase inhibitor FRM-0334 on progranulin levels in patients with progranulin gene haploinsufficiency: A randomized clinical trial Journal Article

In: JAMA Netw. Open, vol. 4, no. 9, pp. e2125584, 2021.

Abstract | BibTeX | Tags:

Thijssen, Elisabeth H; Joie, Renaud La; Strom, Amelia; Fonseca, Corrina; Iaccarino, Leonardo; Wolf, Amy; Spina, Salvatore; Allen, Isabel E; Cobigo, Yann; Heuer, Hilary; VandeVrede, Lawren; Proctor, Nicholas K; Lago, Argentina Lario; Baker, Suzanne; Sivasankaran, Rajeev; Kieloch, Agnieszka; Kinhikar, Arvind; Yu, Lili; Valentin, Marie-Anne; Jeromin, Andreas; Zetterberg, Henrik; Hansson, Oskar; Mattsson-Carlgren, Niklas; Graham, Danielle; Blennow, Kaj; Kramer, Joel H; Grinberg, Lea T; Seeley, William W; Rosen, Howard; Boeve, Bradley F; Miller, Bruce L; Teunissen, Charlotte E; Rabinovici, Gil D; Rojas, Julio C; Dage, Jeffrey L; Boxer, Adam L; Research, Advancing; investigators, Treatment

Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study Journal Article

In: Lancet Neurol., vol. 20, no. 9, pp. 739–752, 2021.

Abstract | BibTeX | Tags:

Edwards, Lauren; Joie, Renaud La; Iaccarino, Leonardo; Strom, Amelia; Baker, Suzanne L; Casaletto, Kaitlin B; Cobigo, Yann; Grant, Harli; Kim, Minseon; Kramer, Joel H; Mellinger, Taylor J; Pham, Julie; Possin, Katherine L; Rosen, Howard J; Soleimani-Meigooni, David N; Wolf, Amy; Miller, Bruce L; Rabinovici, Gil D

Multimodal neuroimaging of sex differences in cognitively impaired patients on the Alzheimer's continuum: greater tau-PET retention in females Journal Article

In: Neurobiol. Aging, vol. 105, pp. 86–98, 2021.

Abstract | BibTeX | Tags: Alzheimer's disease; Amyloid; Apolipoprotein E; Positron emission tomography; Sex differences; Tau

Provost, Karine; Joie, Renaud La; Strom, Amelia; Iaccarino, Leonardo; Edwards, Lauren; Mellinger, Taylor J; Pham, Julie; Baker, Suzanne L; Miller, Bruce L; Jagust, William J; Rabinovici, Gil D

Crossed cerebellar diaschisis on 18F-FDG PET: Frequency across neurodegenerative syndromes and association with 11C-PIB and 18F-Flortaucipir Journal Article

In: J. Cereb. Blood Flow Metab., vol. 41, no. 9, pp. 2329–2343, 2021.

Abstract | BibTeX | Tags: Alzheimer's; FDG; PET; Tau; diaschisis

Strom, Amelia; Iaccarino, Leonardo; Edwards, Lauren; Lesman-Segev, Orit H; Soleimani-Meigooni, David N; Pham, Julie; Baker, Suzanne L; Landau, Susan; Jagust, William J; Miller, Bruce L; Rosen, Howard J; Gorno-Tempini, Maria Luisa; Rabinovici, Gil D; Joie, Renaud La; Initiative, Alzheimer's Disease Neuroimaging

Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease Journal Article

In: Brain, 2021.

Abstract | BibTeX | Tags: Alzheimer's disease; PET; amyloid; hypometabolism; tau

Ossenkoppele, Rik; Smith, Ruben; Mattsson-Carlgren, Niklas; Groot, Colin; Leuzy, Antoine; Strandberg, Olof; Palmqvist, Sebastian; Olsson, Tomas; Jögi, Jonas; Stormrud, Erik; Cho, Hanna; Ryu, Young Hoon; Choi, Jae Yong; Boxer, Adam L; Gorno-Tempini, Maria L; Miller, Bruce L; Soleimani-Meigooni, David; Iaccarino, Leonardo; Joie, Renaud La; Baker, Suzanne; Borroni, Edilio; Klein, Gregory; Pontecorvo, Michael J; Devous, Michael D Sr; Jagust, William J; Lyoo, Chul Hyoung; Rabinovici, Gil D; Hansson, Oskar

Accuracy of tau positron emission tomography as a prognostic marker in preclinical and prodromal Alzheimer disease: A head-to-head comparison against amyloid positron emission tomography and magnetic resonance imaging Journal Article

In: JAMA Neurol., vol. 78, no. 8, pp. 961–971, 2021.

Abstract | BibTeX | Tags:

Provost, Karine; Iaccarino, Leonardo; Soleimani-Meigooni, David N; Baker, Suzanne; Edwards, Lauren; Eichenlaub, Udo; Hansson, Oskar; Jagust, William; Janabi, Mustafa; Joie, Renaud La; Lesman-Segev, Orit; Mellinger, Taylor J; Miller, Bruce L; Ossenkoppele, Rik; Pham, Julie; Smith, Ruben; Sonni, Ida; Strom, Amelia; Mattsson-Carlgren, Niklas; Rabinovici, Gil D; (ADNI), Alzheimer's Disease Neuroimaging Initiative

Comparing ATN-T designation by tau PET visual reads, tau PET quantification, and CSF PTau181 across three cohorts Journal Article

In: Eur. J. Nucl. Med. Mol. Imaging, vol. 48, no. 7, pp. 2259–2271, 2021.

Abstract | BibTeX | Tags: Alzheimer's disease; Biomarkers; CSF; Flortaucipir; PET; Tau

Ossenkoppele, Rik; Leuzy, Antoine; Cho, Hanna; Sudre, Carole H; Strandberg, Olof; Smith, Ruben; Palmqvist, Sebastian; Mattsson-Carlgren, Niklas; Olsson, Tomas; Jögi, Jonas; Stormrud, Erik; Ryu, Young Hoon; Choi, Jae Yong; Initiative, Alzheimer's Disease Neuroimaging; group, PREVENT-AD; Boxer, Adam L; Gorno-Tempini, Maria L; Miller, Bruce L; Soleimani-Meigooni, David; Iaccarino, Leonardo; Joie, Renaud La; Borroni, Edilio; Klein, Gregory; Pontecorvo, Michael J; Devous, Michael D Sr; Villeneuve, Sylvia; Lyoo, Chul Hyoung; Rabinovici, Gil D; Hansson, Oskar

The impact of demographic, clinical, genetic, and imaging variables on tau PET status Journal Article

In: Eur. J. Nucl. Med. Mol. Imaging, vol. 48, no. 7, pp. 2245–2258, 2021.

Abstract | BibTeX | Tags: Alzheimer's disease; A$beta$; Dementia; MCI; PET; Tau

Singleton, Ellen; Hansson, Oskar; Pijnenburg, Yolande A L; Joie, Renaud La; Mantyh, William G; Tideman, Pontus; Stomrud, Erik; Leuzy, Antoine; Johansson, Maurits; Strandberg, Olof; Smith, Ruben; Berendrecht, Evi; Miller, Bruce L; Iaccarino, Leonardo; Edwards, Lauren; Strom, Amelia; Wolters, Emma E; Coomans, Emma; Visser, Denise; Golla, Sandeep S V; Tuncel, Hayel; Bouwman, Femke; Swieten, John Cornelis Van; Papma, Janne M; Berckel, Bart; Scheltens, Philip; Dijkstra, Anke A; Rabinovici, Gil D; Ossenkoppele, Rik

Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease Journal Article

In: J. Neurol. Neurosurg. Psychiatry, vol. 92, no. 8, pp. 872–880, 2021.

Abstract | BibTeX | Tags:

Tsoy, Elena; Strom, Amelia; Iaccarino, Leonardo; Erlhoff, Sabrina J; Goode, Collette A; Rodriguez, Anne-Marie; Rabinovici, Gil D; Miller, Bruce L; Kramer, Joel H; Rankin, Katherine P; Joie, Renaud La; Possin, Katherine L

Detecting Alzheimer's disease biomarkers with a brief tablet-based cognitive battery: sensitivity to A$beta$ and tau PET Journal Article

In: Alzheimers. Res. Ther., vol. 13, no. 1, pp. 36, 2021.

Abstract | BibTeX | Tags: Alzheimer's disease; Biomarkers; Mild cognitive impairment; Neuropsychology; Positron emission tomography; Psychometrics

Joie, Renaud La; Visani, Adrienne V; Lesman-Segev, Orit H; Baker, Suzanne L; Edwards, Lauren; Iaccarino, Leonardo; Soleimani-Meigooni, David N; Mellinger, Taylor; Janabi, Mustafa; Miller, Zachary A; Perry, David C; Pham, Julie; Strom, Amelia; Gorno-Tempini, Maria Luisa; Rosen, Howard J; Miller, Bruce L; Jagust, William J; Rabinovici, Gil D

Association of APOE4 and clinical variability in Alzheimer disease with the pattern of tau- and amyloid-PET Journal Article

In: Neurology, vol. 96, no. 5, pp. e650–e661, 2021.

Abstract | BibTeX | Tags:

Iaccarino, Leonardo; Joie, Renaud La; Lesman-Segev, Orit H; Lee, Eunice; Hanna, Lucy; Allen, Isabel E; Hillner, Bruce E; Siegel, Barry A; Whitmer, Rachel A; Carrillo, Maria C; Gatsonis, Constantine; Rabinovici, Gil D

Association between ambient air pollution and amyloid positron emission tomography positivity in older adults with cognitive impairment Journal Article

In: JAMA Neurol., vol. 78, no. 2, pp. 197–207, 2021.

Abstract | BibTeX | Tags:

Lesman-Segev, Orit H; Joie, Renaud La; Iaccarino, Leonardo; Lobach, Iryna; Rosen, Howard J; Seo, Sang Won; Janabi, Mustafa; Baker, Suzanne L; Edwards, Lauren; Pham, Julie; Olichney, John; Boxer, Adam; Huang, Eric; Gorno-Tempini, Marilu; DeCarli, Charles; Hepker, Mackenzie; Hwang, Ji-Hye L; Miller, Bruce L; Spina, Salvatore; Grinberg, Lea T; Seeley, William W; Jagust, William J; Rabinovici, Gil D

Diagnostic accuracy of amyloid versus 18 F-fluorodeoxyglucose positron emission tomography in autopsy-confirmed dementia Journal Article

In: Ann. Neurol., vol. 89, no. 2, pp. 389–401, 2021.

Abstract | BibTeX | Tags:

Iaccarino, Leonardo; Joie, Renaud La; Edwards, Lauren; Strom, Amelia; Schonhaut, Daniel R; Ossenkoppele, Rik; Pham, Julie; Mellinger, Taylor; Janabi, Mustafa; Baker, Suzanne L; Soleimani-Meigooni, David; Rosen, Howard J; Miller, Bruce L; Jagust, William J; Rabinovici, Gil D

Spatial relationships between molecular pathology and neurodegeneration in the Alzheimer's disease continuum Journal Article

In: Cereb. Cortex, vol. 31, no. 1, pp. 1–14, 2021.

Abstract | BibTeX | Tags: amyloid; neurodegeneration; spatial extent; tau; topography

2020

Soleimani-Meigooni, David N; Iaccarino, Leonardo; Joie, Renaud La; Baker, Suzanne; Bourakova, Viktoriya; Boxer, Adam L; Edwards, Lauren; Eser, Rana; Gorno-Tempini, Maria-Luisa; Jagust, William J; Janabi, Mustafa; Kramer, Joel H; Lesman-Segev, Orit H; Mellinger, Taylor; Miller, Bruce L; Pham, Julie; Rosen, Howard J; Spina, Salvatore; Seeley, William W; Strom, Amelia; Grinberg, Lea T; Rabinovici, Gil D

18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases Journal Article

In: Brain, vol. 143, no. 11, pp. 3477–3494, 2020.

Abstract | BibTeX | Tags: Alzheimer's disease; neurofibrillary tangle; neuropathology; positron emission tomography; tau

Sonni, Ida; Segev, Orit H Lesman; Baker, Suzanne L; Iaccarino, Leonardo; Korman, Deniz; Rabinovici, Gil D; Jagust, William J; Landau, Susan M; Joie, Renaud La; Initiative, Alzheimer's Disease Neuroimaging

Evaluation of a visual interpretation method for tau-PET with 18F-flortaucipir Journal Article

In: Alzheimers Dement. (Amst.), vol. 12, no. 1, pp. e12133, 2020.

Abstract | BibTeX | Tags: Alzheimer's disease; flortaucipir; qualitative assessment; tau positron emission tomography; visual assessment

Europa, Eduardo; Iaccarino, Leonardo; Perry, David C; Weis, Elizabeth; Welch, Ariane E; Rabinovici, Gil D; Miller, Bruce L; Gorno-Tempini, Maria Luisa; Henry, Maya L

Diagnostic assessment in primary progressive aphasia: An illustrative case example Journal Article

In: Am. J. Speech. Lang. Pathol., vol. 29, no. 4, pp. 1833–1849, 2020.

Abstract | BibTeX | Tags:

Lindbergh, Cutter A; Casaletto, Kaitlin B; Staffaroni, Adam M; Joie, Renaud La; Iaccarino, Leonardo; Edwards, Lauren; Tsoy, Elena; Elahi, Fanny; Walters, Samantha M; Cotter, Devyn; You, Michelle; Apple, Alexandra C; Asken, Breton; Neuhaus, John; Rexach, Jessica E; Wojta, Kevin J; Rabinovici, Gil; Kramer, Joel H; Network, Hillblom Aging

Sex-related differences in the relationship between $beta$-amyloid and cognitive trajectories in older adults Journal Article

In: Neuropsychology, vol. 34, no. 8, pp. 835–850, 2020.

Abstract | BibTeX | Tags:

Tondo, Giacomo; Iaccarino, Leonardo; Cerami, Chiara; Vanoli, Giovanna Emilia; Presotto, Luca; Masiello, Valeria; Coliva, Angela; Salvi, Fabrizio; Bartolomei, Ilaria; Mosca, Lorena; Lunetta, Christian; Perani, Daniela

11 C-PK11195 PET-based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis Journal Article

In: Ann. Clin. Transl. Neurol., vol. 7, no. 9, pp. 1513–1523, 2020.

Abstract | BibTeX | Tags:

Bejanin, Alexandre; Tammewar, Gautam; Marx, Gabe; Cobigo, Yann; Iaccarino, Leonardo; Kornak, John; Staffaroni, Adam M; Dickerson, Bradford C; Boeve, Bradley F; Knopman, David S; Gorno-Tempini, Marilu; Miller, Bruce L; Jagust, William J; Boxer, Adam L; Rosen, Howard J; Rabinovici, Gil D

Longitudinal structural and metabolic changes in frontotemporal dementia Journal Article

In: Neurology, vol. 95, no. 2, pp. e140–e154, 2020.

Abstract | BibTeX | Tags:

Tondo, Giacomo; Iaccarino, Leonardo; Caminiti, Silvia Paola; Presotto, Luca; Santangelo, Roberto; Iannaccone, Sandro; Magnani, Giuseppe; Perani, Daniela

The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer's disease Journal Article

In: Alzheimers. Res. Ther., vol. 12, no. 1, pp. 50, 2020.

Abstract | BibTeX | Tags: Early-onset Alzheimer's disease; Microglia activation; Positron emission tomography; [11C]-(R)-PK11195 PET; [18F]-FDG PET

Mantyh, William G; Spina, Salvatore; Lee, Alex; Iaccarino, Leonardo; Soleimani-Meigooni, David; Tsoy, Elena; Mellinger, Taylor J; Grant, Harli; Vandevrede, Lawren; Joie, Renaud La; Lesman-Segev, Orit; Gaus, Stephanie; Possin, Katherine L; Grinberg, Lea T; Miller, Bruce L; Seeley, William W; Rabinovici, Gil D

Tau positron emission tomographic findings in a former US football player with pathologically confirmed chronic traumatic encephalopathy Journal Article

In: JAMA Neurol., vol. 77, no. 4, pp. 517–521, 2020.

Abstract | BibTeX | Tags:

Ranasinghe, Kamalini G; Cha, Jungho; Iaccarino, Leonardo; Hinkley, Leighton B; Beagle, Alexander J; Pham, Julie; Jagust, William J; Miller, Bruce L; Rankin, Katherine P; Rabinovici, Gil D; Vossel, Keith A; Nagarajan, Srikantan S

Neurophysiological signatures in Alzheimer's disease are distinctly associated with TAU, amyloid-$beta$ accumulation, and cognitive decline Journal Article

In: Sci. Transl. Med., vol. 12, no. 534, pp. eaaz4069, 2020.

Abstract | BibTeX | Tags:

Thijssen, Elisabeth H; Joie, Renaud La; Wolf, Amy; Strom, Amelia; Wang, Ping; Iaccarino, Leonardo; Bourakova, Viktoriya; Cobigo, Yann; Heuer, Hilary; Spina, Salvatore; VandeVrede, Lawren; Chai, Xiyun; Proctor, Nicholas K; Airey, David C; Shcherbinin, Sergey; Evans, Cynthia Duggan; Sims, John R; Zetterberg, Henrik; Blennow, Kaj; Karydas, Anna M; Teunissen, Charlotte E; Kramer, Joel H; Grinberg, Lea T; Seeley, William W; Rosen, Howie; Boeve, Bradley F; Miller, Bruce L; Rabinovici, Gil D; Dage, Jeffrey L; Rojas, Julio C; Boxer, Adam L; Research, Advancing; investigators, Treatment

Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration Journal Article

In: Nat. Med., vol. 26, no. 3, pp. 387–397, 2020.

Abstract | BibTeX | Tags:

Joie, Renaud La; Visani, Adrienne V; Baker, Suzanne L; Brown, Jesse A; Bourakova, Viktoriya; Cha, Jungho; Chaudhary, Kiran; Edwards, Lauren; Iaccarino, Leonardo; Janabi, Mustafa; Lesman-Segev, Orit H; Miller, Zachary A; Perry, David C; O'Neil, James P; Pham, Julie; Rojas, Julio C; Rosen, Howard J; Seeley, William W; Tsai, Richard M; Miller, Bruce L; Jagust, William J; Rabinovici, Gil D

Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET Journal Article

In: Sci. Transl. Med., vol. 12, no. 524, pp. eaau5732, 2020.

Abstract | BibTeX | Tags:

Iaccarino, Leonardo; Sala, Arianna; Caminiti, Silvia Paola; Presotto, Luca; Perani, Daniela; Initiative, Alzheimer's Disease Neuroimaging

In vivo MRI structural and PET metabolic connectivity study of dopamine pathways in Alzheimer's disease Journal Article

In: J. Alzheimers. Dis., vol. 75, no. 3, pp. 1003–1016, 2020.

Abstract | BibTeX | Tags: Alzheimer's disease; connectivity; dementia; dopamine systems; mild cognitive impairment; ventro-tegmental area

2019

Perani, Daniela; Iaccarino, Leonardo; Jacobs, Andreas H; Group, IMBI Brain Imaging Working

Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies Journal Article

In: Alzheimers Dement. (Amst.), vol. 11, no. 1, pp. 327–332, 2019.

Abstract | BibTeX | Tags: Amyloid; Neuroinflammation; PET molecular imaging; Protheinopathies; Radiotracers; Tau

Sala, Arianna; Caminiti, Silvia Paola; Iaccarino, Leonardo; Beretta, Luca; Iannaccone, Sandro; Magnani, Giuseppe; Padovani, Alessandro; Ferini-Strambi, Luigi; Perani, Daniela

Vulnerability of multiple large-scale brain networks in dementia with Lewy bodies Journal Article

In: Hum. Brain Mapp., vol. 40, no. 15, pp. 4537–4550, 2019.

Abstract | BibTeX | Tags: FDG; PET; connectivity; default mode network; resting-state network; synuclein

Perani, Daniela; Iaccarino, Leonardo; Lammertsma, Adriaan A; Windhorst, Albert D; Edison, Paul; Boellaard, Ronald; Hansson, Oskar; Nordberg, Agneta; Jacobs, Andreas H; Project, IMBI

A new perspective for advanced positron emission tomography-based molecular imaging in neurodegenerative proteinopathies Journal Article

In: Alzheimers. Dement., vol. 15, no. 8, pp. 1081–1103, 2019.

Abstract | BibTeX | Tags: Amyloid; Neuroinflammation; PET molecular imaging; Protheinopathies; Radiotracers; Tau

Iaccarino, Leonardo; Sala, Arianna; Perani, Daniela; Initiative, Alzheimer's Disease Neuroimaging

Predicting long-term clinical stability in amyloid-positive subjects by FDG-PET Journal Article

In: Ann. Clin. Transl. Neurol., vol. 6, no. 6, pp. 1113–1120, 2019.

Abstract | BibTeX | Tags:

Ossenkoppele, Rik; Iaccarino, Leonardo; Schonhaut, Daniel R; Brown, Jesse A; Joie, Renaud La; O'Neil, James P; Janabi, Mustafa; Baker, Suzanne L; Kramer, Joel H; Gorno-Tempini, Maria-Luisa; Miller, Bruce L; Rosen, Howard J; Seeley, William W; Jagust, William J; Rabinovici, Gil D

Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain Journal Article

In: NeuroImage Clin., vol. 23, no. 101848, pp. 101848, 2019.

Abstract | BibTeX | Tags: Alzheimer's disease; Amyloid; Flortaucipir; Functional connectivity; PET; Tau

Sala, Arianna; Iaccarino, Leonardo; Fania, Piercarlo; Vanoli, Emilia G; Fallanca, Federico; Pagnini, Caterina; Cerami, Chiara; Calvo, Andrea; Canosa, Antonio; Pagani, Marco; Chi`o, Adriano; Cistaro, Angelina; Perani, Daniela

Testing the diagnostic accuracy of [18F]FDG-PET in discriminating spinal- and bulbar-onset amyotrophic lateral sclerosis Journal Article

In: Eur. J. Nucl. Med. Mol. Imaging, vol. 46, no. 5, pp. 1117–1131, 2019.

Abstract | BibTeX | Tags: Amyotrophic lateral sclerosis; Biomarkers; Brain metabolism; Diagnosis; [18F]FDG-PET

Caminiti, Silvia Paola; Sala, Arianna; Iaccarino, Leonardo; Beretta, Luca; Pilotto, Andrea; Gianolli, Luigi; Iannaccone, Sandro; Magnani, Giuseppe; Padovani, Alessandro; Ferini-Strambi, Luigi; Perani, Daniela

Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria Journal Article

In: Alzheimers. Res. Ther., vol. 11, no. 1, pp. 20, 2019.

Abstract | BibTeX | Tags: Biomarker: diagnosis, prognosis; Brain metabolism; Dementia with Lewy bodies; FDG-PET

2018

Iaccarino, Leonardo; Sala, Arianna; Caminiti, Silvia Paola; Santangelo, Roberto; Iannaccone, Sandro; Magnani, Giuseppe; Perani, Daniela

The brain metabolic signature of visual hallucinations in dementia with Lewy bodies Journal Article

In: Cortex, vol. 108, pp. 13–24, 2018.

Abstract | BibTeX | Tags: 18F-FDG-PET; Dementia with Lewy bodies; Metabolic connectivity; NPI; Visual hallucinations

Perani, Daniela; Lalli, Stefania; Iaccarino, Leonardo; Alongi, Pierpaolo; Gambini, Orsola; Franzini, Angelo; Albanese, Alberto

Prefrontal cortical stimulation in tourette disorder: Proof-of-concept clinical and neuroimaging study Journal Article

In: Mov. Disord. Clin. Pract., vol. 5, no. 5, pp. 499–505, 2018.

Abstract | BibTeX | Tags: SPM analysis; Tourette's syndrome; cerebral metabolism; prefrontal cortical stimulation; tics

Presotto, Luca; Iaccarino, Leonardo; Sala, Arianna; Vanoli, Emilia G; Muscio, Cristina; Nigri, Anna; Bruzzone, Maria Grazia; Tagliavini, Fabrizio; Gianolli, Luigi; Perani, Daniela; Bettinardi, Valentino

Low-dose CT for the spatial normalization of PET images: A validation procedure for amyloid-PET semi-quantification Journal Article

In: NeuroImage Clin., vol. 20, pp. 153–160, 2018.

Abstract | BibTeX | Tags: Alzheimer's disease; Amyloid burden; Positron emission tomography/computed tomography; SUVr

Alongi, Pierpaolo; Iaccarino, Leonardo; Losa, Marco; Vecchio, Antonella Del; Gerevini, Simonetta; Plebani, Valentina; Muzio, Nadia Di; Mortini, Pietro; Gianolli, Luigi; Perani, Daniela

PET evaluation of late cerebral effect in advanced radiation therapy techniques for cranial base tumors Journal Article

In: Curr. Radiopharm., vol. 11, no. 2, pp. 86–91, 2018.

Abstract | BibTeX | Tags: 18F-FDG PET ; MRI ; SPM ; gamma knife ; radiotoxicity; tomotherapy

Iaccarino, Leonardo; Moresco, Rosa Maria; Presotto, Luca; Bugiani, Orso; Iannaccone, Sandro; Giaccone, Giorgio; Tagliavini, Fabrizio; Perani, Daniela

An in vivo 11C-(R)-PK11195 PET and in vitro pathology study of microglia activation in Creutzfeldt-Jakob disease Journal Article

In: Mol. Neurobiol., vol. 55, no. 4, pp. 2856–2868, 2018.

Abstract | BibTeX | Tags: Creutzfeldt-Jakob disease; Microglia activation; PET; Postmortem examination; Prion disease

Santos-Santos, Miguel A; Rabinovici, Gil D; Iaccarino, Leonardo; Ayakta, Nagehan; Tammewar, Gautam; Lobach, Iryna; Henry, Maya L; Hubbard, Isabel; Mandelli, Maria Luisa; Spinelli, Edoardo; Miller, Zachary A; Pressman, Peter S; O'Neil, James P; Ghosh, Pia; Lazaris, Andreas; Meyer, Marita; Watson, Christa; Yoon, Soo Jin; Rosen, Howard J; Grinberg, Lea; Seeley, William W; Miller, Bruce L; Jagust, William J; Gorno-Tempini, Maria Luisa

Rates of amyloid imaging positivity in patients with primary progressive aphasia Journal Article

In: JAMA Neurol., vol. 75, no. 3, pp. 342–352, 2018.

Abstract | BibTeX | Tags:

Belloli, Sara; Zanotti, Lucia; Murtaj, Valentina; Mazzon, Cristina; Grigoli, Giuseppe Di; Monterisi, Cristina; Masiello, Valeria; Iaccarino, Leonardo; Cappelli, Andrea; Poliani, Pietro Luigi; Politi, Letterio Salvatore; Moresco, Rosa Maria

18F-VC701-PET and MRI in the in vivo neuroinflammation assessment of a mouse model of multiple sclerosis Journal Article

In: J. Neuroinflammation, vol. 15, no. 1, pp. 33, 2018.

Abstract | BibTeX | Tags: EAE monophasic model; MRI; Multiple sclerosis; Neuroinflammation; TSPO-PET

Iaccarino, Leonardo; Presotto, Luca; Bettinardi, Valentino; Gianolli, Luigi; Roiter, Ignazio; Capellari, Sabina; Parchi, Piero; Cortelli, Pietro; Perani, Daniela

An in vivo 11C-PK PET study of microglia activation in Fatal Familial Insomnia Journal Article

In: Ann. Clin. Transl. Neurol., vol. 5, no. 1, pp. 11–18, 2018.

Abstract | BibTeX | Tags:

Iaccarino, Leonardo; Tammewar, Gautam; Ayakta, Nagehan; Baker, Suzanne L; Bejanin, Alexandre; Boxer, Adam L; Gorno-Tempini, Maria Luisa; Janabi, Mustafa; Kramer, Joel H; Lazaris, Andreas; Lockhart, Samuel N; Miller, Bruce L; Miller, Zachary A; O'Neil, James P; Ossenkoppele, Rik; Rosen, Howard J; Schonhaut, Daniel R; Jagust, William J; Rabinovici, Gil D

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease Journal Article

In: NeuroImage Clin., vol. 17, pp. 452–464, 2018.

Abstract | BibTeX | Tags: Alzheimer's Disease; Amyloid imaging; Brain atrophy; Dementia; Tau imaging

2017

Ardura-Fabregat, A; Boddeke, E W G M; Boza-Serrano, A; Brioschi, S; Castro-Gomez, S; Ceyzériat, K; Dansokho, C; Dierkes, T; Gelders, G; Heneka, Michael T; Hoeijmakers, L; Hoffmann, A; Iaccarino, L; Jahnert, S; Kuhbandner, K; Landreth, G; Lonnemann, N; Löschmann, P A; McManus, R M; Paulus, A; Reemst, K; Sanchez-Caro, J M; Tiberi, A; der Perren, A Van; Vautheny, A; Venegas, C; Webers, A; Weydt, P; Wijasa, T S; Xiang, X; Yang, Y

Targeting Neuroinflammation to treat Alzheimer's disease Journal Article

In: CNS Drugs, vol. 31, no. 12, pp. 1057–1082, 2017.

Abstract | BibTeX | Tags:

Iaccarino, Leonardo; Sala, Arianna; Caminiti, Silvia Paola; Perani, Daniela

The emerging role of PET imaging in dementia Journal Article

In: F1000Res., vol. 6, pp. 1830, 2017.

Abstract | BibTeX | Tags: PET; amyloid; biomarker; dementia; diagnosis; fluorodeoxyglucose; molecular imaging; neuroinflammation; prognosis; tau

Cerami, Chiara; Iaccarino, Leonardo; Perani, Daniela

Molecular imaging of neuroinflammation in neurodegenerative dementias: The role of in vivo PET imaging Journal Article

In: Int. J. Mol. Sci., vol. 18, no. 5, 2017.

Abstract | BibTeX | Tags: 11C-PK11195; Alzheimer's disease; TSPO-PET Imaging; astrocytosis; microglia activation; molecular imaging; neurodegenerative disorders; neuroinflammation

Iaccarino, Leonardo; Chiotis, Konstantinos; Alongi, Pierpaolo; Almkvist, Ove; Wall, Anders; Cerami, Chiara; Bettinardi, Valentino; Gianolli, Luigi; Nordberg, Agneta; Perani, Daniela

A cross-validation of FDG- and amyloid-PET biomarkers in mild cognitive impairment for the risk prediction to dementia due to Alzheimer's disease in a clinical setting Journal Article

In: J. Alzheimers. Dis., vol. 59, no. 2, pp. 603–614, 2017.

Abstract | BibTeX | Tags: 11C-PiB-PET; 18F-FDG-PET; Alzheimer's disease; conversion prediction; dementia; early diagnosis; mild cognitive impairment; prognosis

2016

Ballarini, Tommaso; Iaccarino, Leonardo; Magnani, Giuseppe; Ayakta, Nagehan; Miller, Bruce L; Jagust, William J; Gorno-Tempini, Maria Luisa; Rabinovici, Gil D; Perani, Daniela

Neuropsychiatric subsyndromes and brain metabolic network dysfunctions in early onset Alzheimer's disease Journal Article

In: Hum. Brain Mapp., vol. 37, no. 12, pp. 4234–4247, 2016.

Abstract | BibTeX | Tags: early onset Alzheimer's Disease; frontal lobe; functional networks; metabolic connectivity; neuropsychiatric subsyndromes; positron-emission tomography