Daniela Perani, Leonardo Iaccarino, Andreas H Jacobs, Adriaan A Lammertsma, Agneta Nordberg, Albert D Windhorst, Alexander Gerhard, Alexandra Winkeler, Anthony Gee, Bertrand Kuhnast, Christer Halldin, David Brooks, Elena Rodriguez-Vieitez, Federico E Turkheimer, Francisco López-Picón, Gitte M Knudsen, Johnny Vercouillie, Juha O Rinne, Karl Herholz, Koen Van Laere, Marie Joao Santiago-Ribeiro, Matthias M Herth, Michael A Carroll, Michel Bottlaender, Oskar Hansson, Paul Edison, Rainer Hinz, Ronald Boellaard, Rosa Maria Moresco, Sabina Pappatà
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Volume 11, Pages 327-332
Publication year: 2019

Introduction

A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program – Neurodegenerative Disease Research 2016 “Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration,” aimed at providing a roadmap for the applications of established and new molecular imagingtechniques in dementia.

Methods

We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques.

Results

This approach will enhance efforts to understand the multifactorial etiology of Alzheimer’s disease and other dementias.

Discussion

The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.